{"id":12776,"date":"2017-08-14T11:46:04","date_gmt":"2017-08-14T03:46:04","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=12776"},"modified":"2022-07-21T11:24:24","modified_gmt":"2022-07-21T03:24:24","slug":"mk-571-sodium%ef%bd%9c%e5%a4%9a%e8%97%a5%e8%80%90%e8%97%a5%e8%9b%8b%e7%99%bd-1%ef%bc%88mrp1%ef%bc%89%e6%8a%91%e5%88%b6%e5%8a%91%e8%b2%a8%e8%99%9fk2692","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=12776","title":{"rendered":"MK-571 sodium\uff5c\u591a\u85e5\u8010\u85e5\u86cb\u767d-1\uff08MRP1\uff09\u6291\u5236\u5291\u8ca8\u865fK2692"},"content":{"rendered":"

\u85e5\u7269\u4ee3\u8b1d<\/strong>\u7cfb\u5217\u5546\u54c1<\/strong><\/p>\n

\u6d3b\u9ad4\u5167\u7684\u85e5\u7269\u6216\u7570\u751f\u7269\uff08\u4efb\u4f55\u5916\u4f86\u5316\u5b78\u7269\u8cea\uff09\u5305\u62ec\u5206\u5b50\u7684\u5438\u6536\uff0c\u5206\u4f48\uff0c\u4ee3\u8b1d\u548c\u6392\u6cc4\uff08ADME\uff09\u6240\u6709\u53cd\u61c9\/\u751f\u7406\u6a5f\u5236\u3002\u5206\u5b50\u4e4bMetabolism and Excretion , ADME\u5f71\u97ff\u66b4\u9732\u65bc\u7d44\u7e54\u4e4b\u6fc3\u5ea6\u548c\u52d5\u529b\u5b78\uff0c\u6c7a\u5b9a\u7d66\u4e88\u5316\u5408\u7269\u7684\u4f5c\u7528\u3002 Xenobiotics\u53ef\u4ee5\u901a\u904e\u5404\u7a2e\u751f\u7269\u5316\u5b78\u4fee\u98fe\u5982\u6c27\u5316\u9084\u539f\uff0c\u6c34\u89e3\uff0c\u6c34\u5408\uff0c\u7db4\u5408\uff0c\u7e2e\u5408\u6216\u7570\u69cb\u5316\u800c\u4ee3\u8b1d\uff0c\u76ee\u6a19\u662f\u4f7f\u5206\u5b50\u66f4\u89aa\u6c34\uff0c\u56e0\u6b64\u66f4\u5bb9\u6613\u6392\u6cc4\u3002\u5305\u62ec\u7d30\u80de\u8272\u7d20P450\u9176\uff0c\u651d\u53d6\u548c\u6d41\u51fa\u8f49\u904b\u86cb\u767d\uff08P-\u7cd6\u86cb\u767d\uff0cMDR\u8f49\u904b\u86cb\u767d\uff09\u3002BIOVISION\u63d0\u4f9b\u4e86\u4e00\u7cfb\u5217\u5de5\u5177\uff08\u751f\u7269\u5316\u5b78\uff0c\u86cb\u767d\u8cea\uff0c\u6297\u9ad4\uff0c\u6e2c\u5b9a\u8a66\u5291\u76d2\uff09\uff0c\u7528\u65bc\u7814\u7a76\u9069\u7528\u65bc\u85e5\u7269\u8a2d\u8a08\uff0c\u85e5\u7269\u4ee3\u8b1d\/\u8f49\u904b\uff0c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u85e5\u7269\u4ee3\u8b1d\u9176\u548c\u8f49\u904b\u86cb\u767d\u8868\u9054\u7684\u8868\u9054\/\u8abf\u63a7ADME\u7684\u5404\u500b\u65b9\u9762\uff0c\u9776\u86cb\u767d\u7684\u7d50\u69cb – \u529f\u80fd\u95dc\u4fc2\u7b49\u5546\u54c1<\/p>\n

MK-571 sodium\uff5c\u8ca8\u865f2692<\/strong><\/a><\/span><\/p>\n

A selective, CysLT1\u00a0receptor antagonist and multi-drug resistance protein-1 (MRP1) inhibitor<\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u63cf\u8ff0: MK-571\u9209\u662f\u591a\u85e5\u8010\u85e5\u86cb\u767d-1\uff08MRP1\uff09\u6291\u5236\u5291MK-571\uff08#2691\uff09\u7684\u9209\u9e7d\u3002<\/p>\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/td>\n(E)-\u200b3-\u200b[[[3-\u200b[2-\u200b(7-\u200bchloro-\u200b2-\u200bquinolinyl)ethenyl]phenyl][[3-\u200b(dimethylamino)-\u200b3-\u200boxopropyl]thio]methyl]thio]-\u200bpropanoic acid, sodium salt; L-660,711<\/td>\n<\/tr>\n
Appearance<\/td>\nOff-white solid<\/td>\n<\/tr>\n
CAS #<\/td>\n115103-85-0<\/td>\n<\/tr>\n
Molecular Formula<\/td>\nC\u2082\u2086H\u2082\u2086ClN\u2082O\u2083S\u2082.Na<\/td>\n<\/tr>\n
Molecular Weight<\/td>\n537.07<\/td>\n<\/tr>\n
Purity<\/td>\n\u226595%<\/td>\n<\/tr>\n
Solubility<\/td>\nDMSO (~10 mg\/ml) or PBS (pH 7.2, ~10 mg\/ml)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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