{"id":12265,"date":"2017-07-29T23:22:55","date_gmt":"2017-07-29T15:22:55","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=12265"},"modified":"2022-07-21T13:47:46","modified_gmt":"2022-07-21T05:47:46","slug":"%e5%85%8d%e7%96%ab%e7%90%83%e8%9b%8b%e7%99%bdfc%e7%b5%90%e6%a7%8b%e5%9f%9f%ef%bc%8dige-fc%e7%b5%90%e6%a7%8b%e5%9f%9f-recombinant-immunoglobulin-fc-domains%e8%b2%a8%e8%99%9f-pr00104-14-5","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=12265","title":{"rendered":"\u514d\u75ab\u7403\u86cb\u767dFc\u7d50\u69cb\u57df\uff0dIgE Fc\u7d50\u69cb\u57df | Recombinant Immunoglobulin Fc domains\u8ca8\u865f Pr00104-14.5"},"content":{"rendered":"<p><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"http:\/\/biopioneer.com.tw\/?p=12265\" target=\"_blank\">\u91cd\u7d44\u514d\u75ab\u7403\u86cb\u767dFc\u7d50\u69cb\u57df\uff0dIgE\uff08Ig Fc\u7d50\u69cb\u57df\uff09 | \u8ca8\u865f: Pr00104-14.5<\/a><\/span><\/p>\n<p><span lang=\"ZH-HK\">\u7522\u54c1\u4ecb\u7d39<\/span><span lang=\"EN-US\">: <\/span><span lang=\"EN-US\">Human IgE-Fc domain <\/span><span lang=\"ZH-HK\">\u70ba\u7d93\u7531<\/span><span lang=\"EN-US\">F<\/span><span lang=\"EN-US\">c<\/span><span lang=\"ZH-HK\">\u91cd\u7d44\u4eba\u985e<\/span><span lang=\"EN-US\"> Immunoglobulin epsilon heavy chain constant region\u00a0 (IgE-Fc)<\/span><span lang=\"ZH-HK\">\u4e4b\u91cd\u7d44\u86cb\u767d\u3002\u7d50\u69cb\u53ca\u578b\u5f0f\u70ba<\/span><span lang=\"EN-US\">Disulfide-linked homodimer <\/span><span lang=\"ZH-HK\">\u3002<\/span><span lang=\"EN-US\">Human IgE-Fc domain (V104-G427)-(6xHis) Host: HEK293 <\/span><\/p>\n<p>IgE Recombinant Immunoglobulin Fc domains (Ig Fc domains)<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2021\/08\/Immunoglobuln-Fc-domains-300x191.jpg\" alt=\"Immunoglobuln-Fc-domains\" \/><\/p>\n<p>\u57161.\u56db\u7a2e\u514d\u75ab\u7403\u86cb\u767d\uff08Ig\uff09Classes\u985e\u5225\u6216isotype\u540c\u7a2e\u578b\u53ca\u5176Fc\u7d50\u69cb\u57df\u4e4b\u7d50\u69cb\u793a\u610f\u5716\u3002 Ig Fc\u7d50\u69cb\u57df\u4e0d\u7d50\u5408\u6297\u539f &#8211; \u53c3\u898b\u6297\u9ad4\u540c\u7a2e\u578b\u548c\u4e9e\u578b\u548c<span lang=\"EN-US\">Antibody Effector<\/span>\u6297\u9ad4\u6548\u61c9\u5668\u529f\u80fd\uff0c\u4ee5\u8a73\u7d30\u8aaa\u660e\u6297\u9ad4\u7684\u7d50\u69cb\u548c\u529f\u80fd\u3002<\/p>\n<p><span lang=\"EN-GB\">Antibody Isotypes &amp; Subtypes<\/span><\/p>\n<p>\u5728\u54fa\u4e73\u52d5\u7269\u4e2d\uff0c\u6297\u9ad4\u5206\u70ba\u4e94\u500b\u4e3b\u8981\u985e\u5225\u6216\u540c\u7a2e\u578b<span lang=\"EN-US\">IgA<\/span>\uff0c<span lang=\"EN-US\">IgD<\/span>\uff0c<span lang=\"EN-US\">IgE<\/span>\uff0c<span lang=\"EN-US\">IgG<\/span>\u548c<span lang=\"EN-US\">IgM<\/span>\u3002 \u5b83\u5011\u6839\u64da\u5b83\u5011\u6240\u542b\u7684\u91cd\u93c8\u5206\u5225\u5206\u985e\u70ba<span lang=\"EN-US\">\u03b1<\/span>\uff0c<span lang=\"EN-US\">\u03b4<\/span>\uff0c<span lang=\"EN-US\">\u03b5<\/span>\uff0c<span lang=\"EN-US\">\u03b3<\/span>\u6216<span lang=\"EN-US\">\u03bc<\/span>\u3002 \u6046\u5b9a\u7d50\u69cb\u57df\u7684\u9806\u5e8f\u548c\u6578\u76ee\uff0c\u9278\u93c8\u7d50\u69cb\u548c\u6297\u9ad4\u7684\u5316\u5408\u50f9\u90fd\u4e0d\u540c\u3002 \u6297\u9ad4\u8f15\u93c8\u5206\u70ba\u54fa\u4e73\u52d5\u7269\uff0c<span lang=\"EN-US\">\u03ba<\/span>\u548c<span lang=\"EN-US\">\u03bb<\/span>\u5169\u500b\u985e\u5225\uff0c\u5176\u4e2d<span lang=\"EN-US\">\u03ba<\/span>\u8f15\u934a\u662f\u66f4\u5e38\u898b\u7684\u5169\u7a2e\u3002 \u5118\u7ba1\u9019\u4e9b\u5728\u86cb\u767d\u8cea\u5e8f\u5217\u4e2d\u76f8\u5c0d\u4e0d\u76f8\u4f3c\uff0c\u4f46\u5b83\u5011\u5177\u6709\u76f8\u4f3c\u7684\u7d50\u69cb\u548c\u529f\u80fd\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/absoluteantibody.com\/wp-content\/uploads\/2014\/03\/isotypes.png\" alt=\"\" width=\"382\" height=\"251\" \/><\/p>\n<p><span lang=\"EN-US\">IgG<\/span>\u662f\u6b63\u5e38\u4eba\u8840\u6e05\u4e2d\u6700\u8c50\u5bcc\u7684\u6297\u9ad4\uff0c\u4f54\u514d\u75ab\u7403\u86cb\u767d\u7e3d\u6578\u7684<span lang=\"EN-US\">70-85<\/span>\uff05\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002\u5206\u5b50\u91cf\u7d04<span lang=\"EN-US\">150kDa<\/span>\u662f\u55ae\u9ad4\u7684\uff0c\u662f\u4e8c\u6b21\u514d\u75ab\u53cd\u61c9\u7684\u4e3b\u8981\u6297\u9ad4\uff0c\u5176\u4e94\u500b\u514d\u75ab\u7403\u86cb\u767d\u985e\u5225\u7684\u534a\u8870\u671f\u6700\u9577\uff08<span lang=\"EN-US\">20-24<\/span>\u5929\uff09\u3002<span lang=\"EN-US\"> IgG<\/span>\u7531\u56db\u500b\u4eba\u985e\u4e9e\u985e\uff08<span lang=\"EN-US\">IgG1<\/span>\uff0c<span lang=\"EN-US\">IgG2<\/span>\uff0c<span lang=\"EN-US\">IgG3<\/span>\u548c<span lang=\"EN-US\">IgG4<\/span>\uff09\u7d44\u6210\uff0c\u6bcf\u500b\u542b\u6709\u4e0d\u540c\u7684\u91cd\u93c8\u3002\u5b83\u5011\u662f\u9ad8\u5ea6\u540c\u6e90\u7684\uff0c\u4e3b\u8981\u5728\u9278\u93c8\u5340\u548c\u5b83\u5011\u6fc0\u6d3b\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7d71\u7684\u7a0b\u5ea6\u4e0a\u4e0d\u540c\u3002<span lang=\"EN-US\"> IgG1<\/span>\u548c<span lang=\"EN-US\">IgG4<\/span>\u5728\u9278\u93c8\u5340\u57df\u4e2d\u542b\u6709\u5169\u500b\u93c8\u9593\u4e8c\u786b\u9375\uff0c<span lang=\"EN-US\">IgG2<\/span>\u5177\u6709<span lang=\"EN-US\">4<\/span>\u500b\uff0c<span lang=\"EN-US\">IgG3<\/span>\u5177\u6709<span lang=\"EN-US\">11<\/span>\u500b\u3002\u5728<span lang=\"EN-US\">Fc<\/span>\u6548\u61c9\u5b50\u529f\u80fd\u7684\u90e8\u5206\u5c07\u63cf\u8ff0\u4eba\u985e<span lang=\"EN-US\">IgG<\/span>\u4e9e\u985e\u4e4b\u9593\u529f\u80fd\u5dee\u7570\u7684\u7d30\u7bc0\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c<span lang=\"EN-US\">IgG<\/span>\u985e\u5206\u70ba<span lang=\"EN-US\">5<\/span>\u500b\u4e9e\u985e\uff08<span lang=\"EN-US\">IgG1<\/span>\uff0c<span lang=\"EN-US\">IgG2A<\/span>\uff0c<span lang=\"EN-US\">IgG2B<\/span>\uff0c<span lang=\"EN-US\">IgG2C<\/span>\u548c<span lang=\"EN-US\">IgG3<\/span>\uff09\uff0c\u5927\u9f20\u4e2d\u6709<span lang=\"EN-US\">4<\/span>\u500b\uff08<span lang=\"EN-US\">IgG1<\/span>\uff0c<span lang=\"EN-US\">IgG2A<\/span>\uff0c<span lang=\"EN-US\">IgG2B<\/span>\uff0c<span lang=\"EN-US\">IgG2C<\/span>\uff09\u3002\u6bcf\u500b\u7269\u7a2e\u90fd\u6709\u7368\u7acb\u7684\u5b50\u985e\u547d\u540d\uff0c\u6240\u4ee5\u6bcf\u500b\u7269\u7a2e\u7684\u5b50\u985e\u4e4b\u9593\u6c92\u6709\u4e00\u822c\u7684\u95dc\u4fc2\u3002<\/p>\n<p><span lang=\"EN-US\">IgM<\/span>\u4f54\u514d\u75ab\u7403\u86cb\u767d\u5eab\u7684<span lang=\"EN-US\">5-10<\/span>\uff05\uff0c\u662f\u521d\u7d1a\u514d\u75ab\u61c9\u7b54\u4e2d\u7684\u4e3b\u8981\u6297\u9ad4\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002\u8207<span lang=\"EN-US\">IgG<\/span>\u4e0d\u540c\uff0c<span lang=\"EN-US\">IgM<\/span>\u4e0d\u5305\u542b\u9278\u93c8\u5340\uff0c\u4f46\u5728\u7fa7\u57fa\u672b\u7aef\u542b\u6709\u984d\u5916\u7684\u6046\u5b9a\u7d50\u69cb\u57df\u548c<span lang=\"EN-US\">18<\/span>\u500b\u6c28\u57fa\u9178\u7684\u5c3e\u7aef\uff0c\u5176\u542b\u6709\u534a\u80f1\u6c28\u9178\u4e26\u4e14\u6d89\u53ca\u5206\u5b50\u7684\u591a\u805a\u5316\u3002\u7d93\u5178\u5730\u8868\u793a\u70ba\u7531<span lang=\"EN-US\">J<\/span>\u93c8\u4fdd\u6301\u5728\u4e00\u8d77\u7684\u57fa\u672c\u56db\u93c8\u7d50\u69cb\u7684\u4e94\u805a\u9ad4\uff0c\u4f46\u4e5f\u53ef\u4ee5\u4ee5\u4e0d\u542b<span lang=\"EN-US\">J<\/span>\u93c8\uff08<span lang=\"EN-US\">2<\/span>\uff09\u7684\u516d\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u4e26\u4e14\u4f5c\u70ba<span lang=\"EN-US\">B<\/span>\u7d30\u80de\u8868\u9762\u4e0a\u7684\u55ae\u9ad4\u5b58\u5728\u3002\u53ef\u6eb6\u6027<span lang=\"EN-US\">IgM<\/span>\u8d85\u904e<span lang=\"EN-US\">1 MDa<\/span>\uff0c\u56e0\u6b64\u5176\u5927\u5c0f\u4e3b\u8981\u5c40\u9650\u65bc\u8840\u7ba1\u5167\u6c60\u3002<\/p>\n<p><span lang=\"EN-US\">IgA<\/span>\u4ee3\u8868\u6297\u9ad4\u5eab\u7684\u7d04<span lang=\"EN-US\">5-15<\/span>\uff05\uff0c\u4e26\u4e14\u4f5c\u70ba\u55ae\u9ad4\u6216\u4e8c\u805a\u9ad4\u5b58\u5728\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002<span lang=\"EN-US\"> IgA<\/span>\u662f\u7c98\u6db2\u5206\u6ccc\u7269\u5982\u553e\u6db2\uff0c\u773c\u6dda\uff0c\u725b\u5976\u548c\u8178\u6db2\u4e2d\u4e3b\u8981\u7684\u6297\u9ad4\u3002\u50cf<span lang=\"EN-US\">IgM<\/span>\u4e00\u6a23\uff0c<span lang=\"EN-US\">IgA<\/span>\u7684\u591a\u805a\u9ad4\u5f62\u5f0f\u5728\u7fa7\u57fa\u672b\u7aef\u542b\u6709\u4e00\u500b\u5c3e\u7247\uff0c\u4e26\u88ab<span lang=\"EN-US\">J<\/span>\u93c8\u4fdd\u6301\u5728\u4e00\u8d77\u3002\u5206\u6ccc\u7d44\u5206\u662f\u7531\u8178\u7684\u4e0a\u76ae\u7d30\u80de\u5408\u6210\u7684<span lang=\"EN-US\">75kDa<\/span>\u591a\u80bd\u93c8\uff0c\u7528\u65bc\u9023\u63a5\u5230\u4e8c\u805a\u9ad4\u5f62\u5f0f\u7684<span lang=\"EN-US\">IgA<\/span>\u3002\u9867\u540d\u601d\u7fa9\uff0c\u5206\u6ccc\u7d44\u5206\u6709\u52a9\u65bc\u7a7f\u904e\u4e0a\u76ae\u7d30\u80de\u7684<span lang=\"EN-US\">IgA<\/span>\u8f49\u904b\uff0c\u4f46\u4e5f\u53c3\u8207\u4fdd\u8b77\u5206\u6ccc\u5230\u8178\u8154\u4e2d\u7684<span lang=\"EN-US\">IgA<\/span>\u514d\u65bc\u86cb\u767d\u6c34\u89e3\u6d88\u5316\u3002<\/p>\n<p><span lang=\"EN-US\">IgD<\/span>\u4f54\u7e3d\u8840\u6f3f\u514d\u75ab\u7403\u86cb\u767d\u7684<span lang=\"EN-US\">1<\/span>\uff05\u4ee5\u4e0b\uff0c\u4f46\u5927\u91cf\u5b58\u5728\u65bc<span lang=\"EN-US\">B<\/span>\u7d30\u80de\u819c\u4e0a\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002<span lang=\"EN-US\"> IgD<\/span>\u5177\u6709\u8207<span lang=\"EN-US\">IgG<\/span>\u76f8\u540c\u7684\u57fa\u672c\u7d50\u69cb\uff0c\u4f46\u5177\u6709\u975e\u5e38\u6613\u65bc\u86cb\u767d\u6c34\u89e3\u6d88\u5316\u7684\u5ef6\u4f38\u9278\u93c8\u5340\u3002\u9019\u985e\u6297\u9ad4\u7684\u7cbe\u78ba\u529f\u80fd\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<p><span lang=\"EN-US\">IgE<\/span>\u5728\u8840\u6e05\u4e2d\u975e\u5e38\u7a00\u5c11\uff0c\u4f46\u5728\u6240\u6709\u500b\u9ad4\u7684\u55dc\u9e7c\u6027\u7c92\u7d30\u80de\u548c\u80a5\u5927\u7d30\u80de\u4e0a\u767c\u73fe\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002\u4ee5\u8207<span lang=\"EN-US\">IgM<\/span>\u985e\u4f3c\u7684\u65b9\u5f0f\uff0c<span lang=\"EN-US\">IgE<\/span>\u5177\u6709\u5169\u500b\u984d\u5916\u7684\u6046\u5b9a\u7d50\u69cb\u57df\u4ee3\u66ff\u9278\u93c8\u5340\u3002\u8a72\u985e\u53ef\u80fd\u5c0d\u5bc4\u751f\u87f2\u7684\u514d\u75ab\u529b\u8d77\u4f5c\u7528\uff0c\u4f46\u66f4\u5e38\u898b\u5730\u8207<span lang=\"EN-US\">I<\/span>\u578b\u7acb\u5373\u8d85\u654f\u53cd\u61c9\u76f8\u95dc\uff0c\u5176\u4e2d\u5c0d\u7121\u5bb3\u74b0\u5883\u6297\u539f\u5982\u82b1\u7c89\u548c\u82b1\u751f\u9aee\u751f<span lang=\"EN-US\">IgE<\/span>\u514d\u75ab\u61c9\u7b54\u3002<\/p>\n<p><span id=\"result_box\" lang=\"zh-TW\">\u6297\u9ad4\u7684\u4f5c\u7528\u65b9\u5f0f:<br \/>\n\u6297\u9ad4\u5177\u6709\u5e7e\u7a2e\u4f5c\u7528\u6a21\u5f0f\uff1ai\uff09\u5b83\u5011\u53ef\u4ee5\u963b\u65b7\u914d\u9ad4 &#8211; \u53d7\u9ad4\u76f8\u4e92\u4f5c\u7528; ii\uff09\u901a\u904e\u6fc0\u6d3b\u88dc\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08CDC\uff09\u5f15\u8d77\u7d30\u80de\u88c2\u89e3; iii\uff09\u8207\u6548\u61c9\u7d30\u80de\u4e0a\u7684Fc\u53d7\u9ad4\u76f8\u4e92\u4f5c\u7528\u4ee5\u53c3\u8207\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027; iv\uff09\u901a\u904e\u541e\u566c\u7d30\u80de\u651d\u53d6\u75c5\u539f\u9ad4\u7684\u4fe1\u865f\u3002<\/span><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/absoluteantibody.com\/wp-content\/uploads\/2014\/03\/Effectorfunction.png\" alt=\"\" \/><\/p>\n<p><span lang=\"EN-US\">Fc<\/span>\u53d7\u9ad4\uff08<span lang=\"EN-US\">FcR<\/span>\uff09\u662f\u5c07\u6297\u9ad4\u4ecb\u5c0e\u7684\uff08\u9ad4\u6db2\uff09\u514d\u75ab\u61c9\u7b54\u8207\u7d30\u80de\u6548\u61c9\u5b50\u529f\u80fd\u9023\u63a5\u7684\u95dc\u9375\u7684\u514d\u75ab\u8abf\u7bc0\u53d7\u9ad4\u3002\u5df2\u7d93\u9451\u5b9a\u4e86\u6240\u6709\u985e\u5225\u7684\u514d\u75ab\u7403\u86cb\u767d\u53d7\u9ad4\uff0c\u5305\u62ec<span lang=\"EN-US\">Fc\u03b3R<\/span>\uff08<span lang=\"EN-US\">IgG<\/span>\uff09\uff0c<span lang=\"EN-US\">Fc\u03b5RI<\/span>\uff08<span lang=\"EN-US\">IgE<\/span>\uff09\uff0c<span lang=\"EN-US\">Fc\u03b1RI<\/span>\uff08<span lang=\"EN-US\">IgA<\/span>\uff09\uff0c<span lang=\"EN-US\">Fc\u03bcR<\/span>\uff08<span lang=\"EN-US\">IgM<\/span>\uff09\u548c<span lang=\"EN-US\">Fc\u03b4R<\/span>\uff08<span lang=\"EN-US\">IgD<\/span>\uff09\u3002\u5728\u767d\u7d30\u80de\u4e0a\u5b58\u5728\u4e09\u7a2e\u985e\u578b\u7684\u4eba<span lang=\"EN-US\">IgG<\/span>\u53d7\u9ad4\uff1a<span lang=\"EN-US\">CD64<\/span>\uff08<span lang=\"EN-US\">Fc\u03b3RI<\/span>\uff09\uff0c<span lang=\"EN-US\">CD32<\/span>\uff08<span lang=\"EN-US\">Fc\u03b3RIIa<\/span>\uff0c<span lang=\"EN-US\">Fc\u03b3RIIb<\/span>\u548c<span lang=\"EN-US\">Fc\u03b3RIIc<\/span>\uff09\u548c<span lang=\"EN-US\">CD16<\/span>\uff08<span lang=\"EN-US\">Fc\u03b3RIIIa<\/span>\u548c<span lang=\"EN-US\">Fc\u03b3RIIIb<\/span>\uff09\u3002<span lang=\"EN-US\"> Fc\u03b3RI<\/span>\u88ab\u6b78\u985e\u70ba\u9ad8\u89aa\u548c\u529b\u53d7\u9ad4\uff08\u7d0d\u6469\u723e\u7bc4\u570d<span lang=\"EN-US\">KD<\/span>\uff09\uff0c\u800c<span lang=\"EN-US\">Fc\u03b3RII<\/span>\u548c<span lang=\"EN-US\">Fc\u03b3RIII<\/span>\u4f4e\u81f3\u4e2d\u7b49\u89aa\u548c\u529b\uff08\u5fae\u6469\u723e\u7bc4\u570d<span lang=\"EN-US\">KD<\/span>\uff09\uff08<span lang=\"EN-US\">1<\/span>\uff09\u3002<\/p>\n<p>\u5728\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08<span lang=\"EN-US\">ADCC<\/span>\uff09\u4e2d\uff0c\u6548\u61c9\u7d30\u80de\uff08\u5929\u7136\u6bba\u50b7\u7d30\u80de\uff0c\u5de8\u566c\u7d30\u80de\uff0c\u55ae\u6838\u7d30\u80de\u548c\u55dc\u9178\u6027\u7c92\u7d30\u80de\uff09\u8868\u9762\u4e0a\u7684<span lang=\"EN-US\">FcvR<\/span>\u8207\u672c\u8eab\u7d50\u5408\u65bc\u9776\u7d30\u80de\u7684<span lang=\"EN-US\">IgG<\/span>\u7684<span lang=\"EN-US\">Fc<\/span>\u5340\u7d50\u5408\u3002\u5728\u7d50\u5408\u6642\uff0c\u89f8\u767c\u4fe1\u865f\u901a\u8def\uff0c\u5176\u5c0e\u81f4\u5404\u7a2e\u7269\u8cea\u7684\u5206\u6ccc\uff0c\u4f8b\u5982\u6eb6\u89e3\u9176\uff0c\u7a7f\u5b54\u7d20\uff0c\u9846\u7c92\u9176\u548c\u816b\u7624\u58de\u6b7b\u56e0\u5b50\uff0c\u5176\u4ecb\u5c0e\u9776\u7d30\u80de\u7684\u7834\u58de\u3002\u5c0d\u65bc\u4eba<span lang=\"EN-US\">IgG<\/span>\u4e9e\u578b\uff0c<span lang=\"EN-US\">ADCC<\/span>\u6548\u61c9\u5b50\u529f\u80fd\u6c34\u5e73\u5404\u4e0d\u76f8\u540c\u3002\u5118\u7ba1\u9019\u53d6\u6c7a\u65bc\u540c\u7a2e\u7570\u578b\u548c\u7279\u7570\u6027<span lang=\"EN-US\">FcvR<\/span>\u7c21\u55ae\u4f86\u8aaa\uff0c<span lang=\"EN-US\">ADCC<\/span>\u6548\u61c9\u5b50\u529f\u80fd\u5c0d\u65bc\u4eba<span lang=\"EN-US\">IgG1<\/span>\u548c<span lang=\"EN-US\">IgG3<\/span>\u662f\u9ad8\u7684\uff0c\u5c0d\u65bc<span lang=\"EN-US\">IgG2<\/span>\u548c<span lang=\"EN-US\">IgG4<\/span>\u800c\u8a00\u662f\u4f4e\u7684\u3002\u5982\u4ee5\u4e0b\u6a21\u578b\u6240\u793a\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/absoluteantibody.com\/wp-content\/uploads\/2014\/03\/FcR.png\" alt=\"\" \/><\/p>\n<p>\u4eba<span lang=\"EN-US\">IgG1-Fc\u03b3RIII<\/span>\u8907\u5408\u7269\u3002<\/p>\n<p>\u8207<span lang=\"EN-US\">Fc\u03b3<\/span>\u53d7\u9ad4<span lang=\"EN-US\">III<\/span>\u8907\u5408\u7684\u4eba<span lang=\"EN-US\">IgG1<\/span>\u7684\u6a21\u578b\uff0c\u5176\u5728\u6297\u9ad4\u7684\u9278\u934a\u548c\u4e0a<span lang=\"EN-US\">CH2<\/span>\u5340\u57df\u4e0a\u4e0d\u5c0d\u7a31\u5730\u7d50\u5408\u3002 \u5de6\u624b\u5716\u50cf\u986f\u793a\u8272\u5e36\u9336\u793a\uff0c\u53f3\u5074\u986f\u793a\u7a7a\u683c\u586b\u5145\u6a21\u578b\u3002 \u6297\u9ad4\u91cd\u934a\u548c\u8f15\u93c8\u5206\u5225\u986f\u793a\u70ba\u85cd\u8272\u548c\u7da0\u8272\uff0c\u6a59\u8272\u7cd6\u57fa\u5316\uff0c\u7d05\u8272\u70ba<span lang=\"EN-US\">Fc\u03b3RIII<\/span>\u3002 \u7531<span lang=\"EN-US\">PDB<\/span>\u767b\u9304\u865f<span lang=\"EN-US\">1IGY<\/span>\u548c<span lang=\"EN-US\">1E4K<\/span>\u751f\u7522\u7684\u6a21\u578b\u3002<\/p>\n<p><span lang=\"EN-US\">Fc\u03b3Rs<\/span>\u901a\u904e\u9278\u934a\u548c\u4e0a<span lang=\"EN-US\">CH2<\/span>\u5340\u57df\u4e0d\u5c0d\u7a31\u5730\u7d50\u5408<span lang=\"EN-US\">IgG<\/span>\u3002\u7d50\u5408\u4f4d\u9ede\u7684\u77e5\u8b58\u5df2\u7d93\u5c0e\u81f4\u4e86\u5de5\u7a0b\u4e0a\u7684\u52aa\u529b\u4f86\u8abf\u7bc0<span lang=\"EN-US\">IgG<\/span>\u6548\u61c9\u5b50\u529f\u80fd<span lang=\"EN-US\"> &#8211; <\/span>\u8a73\u898b<span lang=\"EN-US\">Fc<\/span>\u5de5\u7a0b\u90e8\u5206\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<thead>\n<tr>\n<td width=\"140\"><strong>Catalog Number<\/strong><\/td>\n<td width=\"210\"><strong>Product Name<\/strong><\/td>\n<td width=\"266\"><strong>Product Page<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Pr00100-10.5<\/td>\n<td width=\"210\">Recombinant Human IgG1-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00100-10.5.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00101-1.5<\/td>\n<td width=\"210\">Recombinant Mouse IgG1-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00101-1.5NC.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00102-2.5<\/td>\n<td width=\"210\">Recombinant Mouse IgG2A-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00102-2.5NC.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00104-14.5<\/td>\n<td width=\"210\">Recombinant Human IgE-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00104-14.5.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00105-16.5<\/td>\n<td width=\"210\">Recombinant Human IgA-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00105-16.5.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00107-20.5<\/td>\n<td width=\"210\">Recombinant Mouse IgE-Fc domain<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00107-20.5.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<tr>\n<td>Pr00108-15.5<\/td>\n<td width=\"210\">Recombinant Human LMW IgM-Fc domain (monomeric)<\/td>\n<td width=\"266\"><a href=\"http:\/\/cdn.absoluteantibody.com\/wp-content\/uploads\/PR00108-15.5.pdf\">View Datasheet<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u91cd\u7d44\u514d\u75ab\u7403\u86cb\u767dFc\u7d50\u69cb\u57df\uff0dIgE\uff08Ig Fc\u7d50\u69cb\u57df\uff09 | \u8ca8\u865f: Pr00104-14.5 \u7522\u54c1\u4ecb\u7d39: Hum [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[461],"tags":[3426],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12265"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12265"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12265\/revisions"}],"predecessor-version":[{"id":28851,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12265\/revisions\/28851"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/3519"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12265"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}