{"id":11190,"date":"2017-06-28T12:57:21","date_gmt":"2017-06-28T04:57:21","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=11190"},"modified":"2022-07-21T16:41:35","modified_gmt":"2022-07-21T08:41:35","slug":"11190","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=11190","title":{"rendered":"CHIR-98014\u6291\u5236\u5291 | A potent GSK3 inhibitor\u8ca8\u865f9595-5"},"content":{"rendered":"

\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u95dc\u7814\u7a76-\u814e\u640d\u50b7\/\u814e\u75c5<\/strong><\/p>\n

\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u662f\u5168\u7403\u767c\u75c5\u548c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 CVD\u7684\u57fa\u790e\u5305\u62ec\u5c0d\u6700\u7d42\u963b\u7919\u8840\u6db2\u6d41\u52d5\u7684\u5fc3\u81df\u548c\u8840\u7ba1\u7684\u640d\u5bb3\u3002 \u9019\u7a2e\u5ee3\u6cdb\u7684\u75be\u75c5\u5305\u62ec\u51a0\u72c0\u52d5\u8108\u75be\u75c5\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\u6216\u5fc3\u81df\u75c5\u767c\u4f5c\uff0c\u5fc3\u7d5e\u75db\u7b49\uff09\uff0c\u5fc3\u5f8b\u5931\u5e38\uff0c\u4e2d\u98a8\uff0c\u5148\u5929\u6027\u5fc3\u81df\u75c5\u548c\u814e\/\u8840\u7ba1\u75be\u75c5\u3002 CVD\u7684\u591a\u91cd\u5371\u96aa\u56e0\u7d20\u5305\u62ec\u5e74\u9f61\uff0c\u98f2\u98df\uff0c\u751f\u6d3b\u7fd2\u6163\u8b8a\u5316\uff0c\u907a\u50b3\u50be\u5411\u548c\u9ad8\u8840\u58d3\u5bb6\u65cf\u53f2\uff0c\u7cd6\u5c3f\u75c5\u548c\/\u6216\u80a5\u80d6\u3002 BioVision\u63d0\u4f9b\u5168\u9762\u7684\u7522\u54c1\u7d44\u5408\uff0c\u5305\u62ec\u6e2c\u5b9a\u8a66\u5291\u76d2\uff0c\u91cd\u7d44\u86cb\u767d\uff0c\u6297\u9ad4\u548c\u751f\u7269\u5316\u5b78\u54c1\uff0c\u4ee5\u4fc3\u9032\u5fc3\u8840\u7ba1\u751f\u7269\u5b78\uff0c\u85e5\u7269\u958b\u767c\u548c\u751f\u7269\u6a19\u8a8c\u7269\u767c\u73fe\u7814\u7a76\u3002<\/p>\n

CHIR-98014 – A potent GSK3 inhibitor| <\/em><\/strong>\u8ca8\u865f<\/em><\/strong>9595-5<\/a><\/span><\/p>\n

\u539f\u7406\u4ecb\u7d39<\/strong>:<\/strong> \u7d30\u80de\u6ef2\u900f\u6027CHIR-98014\u662fGSK3\u03b1\u548cGSK3\u03b2\u7684\u6709\u6548\u9078\u64c7\u6027\u548cATP\u7af6\u722d\u6027\u6291\u5236\u5291\uff08\u5206\u5225\u70baIC 50 = 0.65\u548c0.58nM\uff09\u3002 \u6b64\u5916\uff0cCHIR-98014\u6bd4\u5176\u4ed6\u86cb\u767d\u6fc0\u9176\u5982cdc2\u548cERK2\u986f\u793a\u51fa\u5c0dGSK3\u7684\u9078\u64c7\u6027\u5927\u65bc1000\u500d\u81f3\u5927\u65bc1000\u500d\u3002 CHIR98014\u9084\u964d\u4f4e\u5927\u9f20\u8166\u4e2d\u7684tau\u78f7\u9178\u5316\uff0c\u4e26\u652f\u6301\u6210\u9aa8\u671f\u9593\u7684Wnt\u4fe1\u865f\u50b3\u5c0e\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CT 98014<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n556813-39-9<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2080H\u2081\u2087Cl\u2082N\u2089O\u2082<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n486.31<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n>98% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (~ 4 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nC1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C20H17Cl2N9O2\/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17\/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nMDZCSIDIPDZWKL-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n53396311<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u5546\u54c1<\/span>\u00a0AHU-377<\/a>\u00a0|\u00a0CHIR-98014<\/a>\u00a0|\u00a0C-\u53cd\u61c9\u86cb\u767d\uff08CRP\uff09ELISA\u8a66\u5291\u76d2<\/a>\u00a0|\u00a0\u00a0AT 56<\/a>\u00a0|\u00a0<\/span>\u767d\u86cb\u767d\u5c0d\u808c\u9150\u6bd4\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/span><\/p>\n

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