{"id":11182,"date":"2017-06-28T12:48:41","date_gmt":"2017-06-28T04:48:41","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=11182"},"modified":"2022-07-21T16:41:43","modified_gmt":"2022-07-21T08:41:43","slug":"11182","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=11182","title":{"rendered":"AT 56\u6291\u5236\u5291 | inhibitor of L-PGDS \u8ca8\u865f9592-25"},"content":{"rendered":"

\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u95dc\u7814\u7a76-\u814e\u640d\u50b7\/\u814e\u75c5<\/strong><\/p>\n

\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u662f\u5168\u7403\u767c\u75c5\u548c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 CVD\u7684\u57fa\u790e\u5305\u62ec\u5c0d\u6700\u7d42\u963b\u7919\u8840\u6db2\u6d41\u52d5\u7684\u5fc3\u81df\u548c\u8840\u7ba1\u7684\u640d\u5bb3\u3002 \u9019\u7a2e\u5ee3\u6cdb\u7684\u75be\u75c5\u5305\u62ec\u51a0\u72c0\u52d5\u8108\u75be\u75c5\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\u6216\u5fc3\u81df\u75c5\u767c\u4f5c\uff0c\u5fc3\u7d5e\u75db\u7b49\uff09\uff0c\u5fc3\u5f8b\u5931\u5e38\uff0c\u4e2d\u98a8\uff0c\u5148\u5929\u6027\u5fc3\u81df\u75c5\u548c\u814e\/\u8840\u7ba1\u75be\u75c5\u3002 CVD\u7684\u591a\u91cd\u5371\u96aa\u56e0\u7d20\u5305\u62ec\u5e74\u9f61\uff0c\u98f2\u98df\uff0c\u751f\u6d3b\u7fd2\u6163\u8b8a\u5316\uff0c\u907a\u50b3\u50be\u5411\u548c\u9ad8\u8840\u58d3\u5bb6\u65cf\u53f2\uff0c\u7cd6\u5c3f\u75c5\u548c\/\u6216\u80a5\u80d6\u3002 BioVision\u63d0\u4f9b\u5168\u9762\u7684\u7522\u54c1\u7d44\u5408\uff0c\u5305\u62ec\u6e2c\u5b9a\u8a66\u5291\u76d2\uff0c\u91cd\u7d44\u86cb\u767d\uff0c\u6297\u9ad4\u548c\u751f\u7269\u5316\u5b78\u54c1\uff0c\u4ee5\u4fc3\u9032\u5fc3\u8840\u7ba1\u751f\u7269\u5b78\uff0c\u85e5\u7269\u958b\u767c\u548c\u751f\u7269\u6a19\u8a8c\u7269\u767c\u73fe\u7814\u7a76\u3002<\/p>\n

AT 56 – A selective, competitive, and highly bioavailable inhibitor of L-PGDS (lipocalin-type prostaglandin D synthase) | <\/em><\/strong>\u8ca8\u865f<\/em><\/strong>9592-25<\/span><\/a><\/span><\/span><\/p>\n

\u539f\u7406\u4ecb\u7d39<\/strong>:<\/strong> AT-56\u662fL-PGDS\uff08\u8102\u8cea\u904b\u8f09\u86cb\u767d\u578b\u524d\u5217\u817a\u7d20D\u5408\u6210\u9176\uff09\uff08Ki =75\u03bcM\uff09\u7684\u9078\u64c7\u6027\uff0c\u7af6\u722d\u6027\u548c\u9ad8\u5ea6\u751f\u7269\u5229\u7528\u5ea6\u7684\u6291\u5236\u5291\u3002 \u5b83\u6291\u5236\u7531\u4ebaCSF\u7522\u751f\u7684L-PGDS\u548cIC 50\u503c\u70ba95\u03bcM\u7684\u91cd\u7d44\u5c0f\u9f20\u7d30\u80de\u7522\u751fPGD2\u3002 \u5728\u9ad4\u5916\u6fc3\u5ea6\u9ad8\u9054100\u03bcM\u6216\u9ad4\u516730mg \/ kg\u7684\u6fc3\u5ea6\u4e0b\uff0cAT-56\u4e0d\u5f71\u97ffPGE2\uff0cPGF2\u03b1\u6216H-PGDS\u50ac\u5316\u7684PGD2\u7684\u7522\u751f\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n162640-98-4<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2085H\u2082\u2087N\u2085<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n397.52<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (>15 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nC1CN(CCC1=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CCCCC5=NNN=N5<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C25H27N5\/c1-3-9-22-19(7-1)12-13-20-8-2-4-10-23(20)25(22)21-14-17-30(18-15-21)16-6-5-11-24-26-28-29-27-24\/h1-4,7-10,12-13H,5-6,11,14-18H2,(H,26,27,28,29)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nLQNGMDUIRLSESZ-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n11741525<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u5546\u54c1<\/span>\u00a0AHU-377<\/a>\u00a0|\u00a0CHIR-98014<\/a>\u00a0|\u00a0C-\u53cd\u61c9\u86cb\u767d\uff08CRP\uff09ELISA\u8a66\u5291\u76d2<\/a>\u00a0|\u00a0\u00a0AT 56<\/a>\u00a0|\u00a0<\/span>\u767d\u86cb\u767d\u5c0d\u808c\u9150\u6bd4\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u95dc\u7814\u7a76-\u814e\u640d\u50b7\/\u814e\u75c5 \u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u662f\u5168\u7403\u767c\u75c5\u548c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 CVD\u7684\u57fa\u790e\u5305\u62ec\u5c0d\u6700\u7d42\u963b\u7919 […]<\/p>\n","protected":false},"author":3,"featured_media":9204,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[3559],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11182"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11182"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11182\/revisions"}],"predecessor-version":[{"id":11294,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11182\/revisions\/11294"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/9204"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11182"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}