{"id":11179,"date":"2017-06-28T12:39:59","date_gmt":"2017-06-28T04:39:59","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=11179"},"modified":"2022-07-21T16:41:53","modified_gmt":"2022-07-21T08:41:53","slug":"ahu-377-a-potent-and-selective-neprilysin-inhibitor%e8%b2%a8%e8%99%9f9520-25","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=11179","title":{"rendered":"AHU-377 | A potent and selective neprilysin inhibitor\u8ca8\u865f9520-25"},"content":{"rendered":"

\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u95dc\u7814\u7a76-\u814e\u640d\u50b7\/\u814e\u75c5<\/strong><\/a><\/span><\/p>\n

\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u662f\u5168\u7403\u767c\u75c5\u548c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 CVD\u7684\u57fa\u790e\u5305\u62ec\u5c0d\u6700\u7d42\u963b\u7919\u8840\u6db2\u6d41\u52d5\u7684\u5fc3\u81df\u548c\u8840\u7ba1\u7684\u640d\u5bb3\u3002 \u9019\u7a2e\u5ee3\u6cdb\u7684\u75be\u75c5\u5305\u62ec\u51a0\u72c0\u52d5\u8108\u75be\u75c5\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\u6216\u5fc3\u81df\u75c5\u767c\u4f5c\uff0c\u5fc3\u7d5e\u75db\u7b49\uff09\uff0c\u5fc3\u5f8b\u5931\u5e38\uff0c\u4e2d\u98a8\uff0c\u5148\u5929\u6027\u5fc3\u81df\u75c5\u548c\u814e\/\u8840\u7ba1\u75be\u75c5\u3002 CVD\u7684\u591a\u91cd\u5371\u96aa\u56e0\u7d20\u5305\u62ec\u5e74\u9f61\uff0c\u98f2\u98df\uff0c\u751f\u6d3b\u7fd2\u6163\u8b8a\u5316\uff0c\u907a\u50b3\u50be\u5411\u548c\u9ad8\u8840\u58d3\u5bb6\u65cf\u53f2\uff0c\u7cd6\u5c3f\u75c5\u548c\/\u6216\u80a5\u80d6\u3002 BioVision\u63d0\u4f9b\u5168\u9762\u7684\u7522\u54c1\u7d44\u5408\uff0c\u5305\u62ec\u6e2c\u5b9a\u8a66\u5291\u76d2\uff0c\u91cd\u7d44\u86cb\u767d\uff0c\u6297\u9ad4\u548c\u751f\u7269\u5316\u5b78\u54c1\uff0c\u4ee5\u4fc3\u9032\u5fc3\u8840\u7ba1\u751f\u7269\u5b78\uff0c\u85e5\u7269\u958b\u767c\u548c\u751f\u7269\u6a19\u8a8c\u7269\u767c\u73fe\u7814\u7a76\u3002<\/p>\n

\"\"<\/p>\n

AHU-377 – A potent and selective neprilysin inhibitor | <\/em><\/strong>\u8ca8\u865f<\/em><\/strong>9520-25<\/a><\/span><\/p>\n

AHU-377<\/strong>\u539f\u7406\u4ecb\u7d39<\/strong>:<\/strong> AHU-377\u662f\u5728\u9ad4\u5167\u901a\u904e\u916f\u9176\u6d3b\u5316\u4ee5\u5f62\u6210\u6d3b\u6027\u5316\u5408\u7269LBQ657\u7684\u524d\u85e5\uff0c\u5176\u4f5c\u70ba\u6709\u6548\u548c\u9078\u64c7\u6027\u7684\u5c3f\u4e19\u6c28\u9178\u6291\u88fd\u5291\u3002 \u814e\u4e0a\u817a\u7d20\u662f\u8ca0\u8cac\u5fc3\u623f\u548c\u8166\u9209\u7d20\u80bd\u964d\u89e3\u7684\u86cb\u767d\u9176\u3002 \u6291\u5236\u5c3f\u4e19\u6c28\u9178\u80fd\u9632\u6b62\u5229\u5c3f\u9209\u80bd\u7684\u964d\u89e3\uff0c\u4e26\u6fc0\u6d3b\u8abf\u7bc0\u9ad4\u7a4d\u548c\u8840\u58d3\u7684cGMP\u4fe1\u865f\u901a\u8def\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/th>\n4-(((2S,4R)-1-([1,1′-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril<\/td>\n<\/tr>\n
Appearance<\/th>\nLight yellow oil<\/td>\n<\/tr>\n
CAS #<\/th>\n149709-62-6<\/td>\n<\/tr>\n
Molecular Formula<\/th>\nC\u2082\u2084H\u2082\u2089NO\u2085<\/td>\n<\/tr>\n
Molecular Weight<\/th>\n411.49<\/td>\n<\/tr>\n
Purity<\/th>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/th>\nDMSO (>5 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/th>\nCCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O<\/td>\n<\/tr>\n
InChi<\/th>\nInChI=1S\/C24H29NO5\/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19\/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)\/t17-,21+\/m1\/s1<\/td>\n<\/tr>\n
InChi Key<\/th>\nPYNXFZCZUAOOQC-UTKZUKDTSA-N<\/td>\n<\/tr>\n
PubChem CID<\/th>\n9811834<\/a><\/td>\n<\/tr>\n
Handling<\/th>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u5546\u54c1<\/span>\u00a0AHU-377<\/a>\u00a0|\u00a0CHIR-98014<\/a>\u00a0|\u00a0C-\u53cd\u61c9\u86cb\u767d\uff08CRP\uff09ELISA\u8a66\u5291\u76d2<\/a>\u00a0|\u00a0\u00a0AT 56<\/a>\u00a0|\u00a0<\/span>\u767d\u86cb\u767d\u5c0d\u808c\u9150\u6bd4\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u95dc\u7814\u7a76-\u814e\u640d\u50b7\/\u814e\u75c5 \u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u662f\u5168\u7403\u767c\u75c5\u548c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 CVD\u7684\u57fa\u790e\u5305\u62ec\u5c0d\u6700\u7d42\u963b\u7919 […]<\/p>\n","protected":false},"author":3,"featured_media":9204,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[451],"tags":[3560],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11179"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11179"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11179\/revisions"}],"predecessor-version":[{"id":11295,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/11179\/revisions\/11295"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/9204"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11179"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}