{"id":10270,"date":"2017-05-17T18:14:10","date_gmt":"2017-05-17T10:14:10","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=10270"},"modified":"2022-07-22T10:26:55","modified_gmt":"2022-07-22T02:26:55","slug":"at2%e5%9f%ba%e5%9b%a0%e6%95%b2%e9%99%a4%e7%b4%b0%e8%83%9e%e6%a0%aa-%e6%b0%b8%e7%94%9f%e5%b0%8f%e9%bc%a0%e8%85%8e%e8%bf%91%e7%ab%af%e5%b0%8f%e7%ae%a1%e7%b4%b0%e8%83%9e%e7%b3%bb%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=10270","title":{"rendered":"AT2\u57fa\u56e0\u6572\u9664\u7d30\u80de\u682a | \u6c38\u751f\u5c0f\u9f20\u814e\u8fd1\u7aef\u5c0f\u7ba1\u7d30\u80de\u7cfb\/\u7d30\u80de\u6c34\u5e73\u85e5\u7269\u7be9\u9078 (\u8ca8\u865fT0625)"},"content":{"rendered":"

\u85e5\u7269\u6a19\u9776<\/strong> | <\/strong>Drug Discovery-<\/strong>\u7d30\u80de\u5e73\u53f0\u7cfb\u5217\u5546\u54c1<\/strong><\/span><\/p>\n

Angiotensin Receptors Drug Discovery Stable Cell Lines<\/p>\n

AT2<\/strong>\u57fa\u56e0<\/strong>\u6572\u9664\u6c38\u751f\u5c0f\u9f20\u814e\u8fd1\u7aef\u5c0f\u7ba1\u7d30\u80de\u7cfb (<\/strong>\u8ca8\u865f<\/strong>T0625<\/strong>)<\/strong><\/a><\/span><\/p>\n

\u7d30\u80de\u6c34\u5e73\u7684\u85e5\u7269\u7be9\u9078<\/strong>\uff0c\u662f\u63a5\u8fd1\u751f\u7406\u689d\u4ef6\u7684\u4e00\u7a2e\u85e5\u7269\u7be9\u9078\u6a21\u5f0f\uff1b\u6392\u9664\u751f\u5316\u6c34\u5e73\u4e4b\u85e5\u7269\u7be9\u9078\u6a21\u578b\uff0c\u4e4b\u6613\u53d7\u9776\u9176\u7684\u4f5c\u7528\u7a0b\u5ea6\uff0c\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8b1d\u3001\u6392\u6cc4\u7b49\u53c3\u6578\u4e0d\u78ba\u5b9a\u56e0\u7d20\u5f71\u97ff\uff0c\u4f7f\u8aa4\u7be9\u7387\u66f4\u9ad8\u3002\u7d30\u80de\u6c34\u5e73\u4e4b\u85e5\u7269\u7be9\u9078\uff0c\u66f4\u63a5\u8fd1\u751f\u7406\u689d\u4ef6\uff0c\u8b93\u7be9\u9078\u7684\u6e96\u78ba\u7387\u66f4\u9ad8\u3002Abmgood\u63d0\u4f9b\u4e00\u7cfb\u5217\u7d30\u80de\u6c34\u5e73\u4e4b\u85e5\u7269\u6a21\u578b\uff0c\u52a0\u901f\u65b0\u85e5\u767c\u73fe\u548c\u751f\u7269\u91ab\u5b78\u7814\u7a76\u3002\u7d93\u904e\u9a57\u8b49\u751f\u6210\u4e86\u4e00\u500b\u7368\u7279\u7684G\u86cb\u767d\u5076\u806f\u53d7\u9ad4\uff08GPCR\uff09\u5eab\u3001\u6fc0\u9176\u3001\u6838\u6fc0\u7d20\u53d7\u9ad4\uff08NHR\uff09\u548c\u96e2\u5b50\u901a\u9053\u4e4b\u7a69\u5b9a\u7d30\u80de\u7cfb\u5eab\uff0c\u70ba\u6240\u6709\u7814\u7a76\u9805\u76ee\u63d0\u4f9b\u4e86\u5f37\u5927\u7684\u6aa2\u6e2c\u5e73\u53f0\u3002<\/p>\n

\"\"<\/p>\n

AT2<\/strong>\u57fa\u56e0<\/strong>\u6572\u9664<\/strong>\u7d30\u80de\u4ecb\u7d39<\/strong>:<\/strong> \u8fd1\u7aef\u5c0f\u7ba1\u662f\u814e\u81df\u814e\u81df\u7ba1\u7cfb\u7d71\u7684\u4e00\u90e8\u5206\uff0c\u6d89\u53ca\u814e\u7d20 – \u8840\u7ba1\u7dca\u5f35\u7d20\u7cfb\u7d71\u7684\u8abf\u7bc0\u3002\u8a72\u5340\u57df\u7684\u7d30\u80de\u6709\u52a9\u65bc\u8abf\u7bc0\u9209\u548c\u9ad4\u7a4d\u7684\u9ad4\u5167\u5e73\u8861\u4ee5\u53ca\u8abf\u7bc0\u5168\u8eab\u8840\u58d3\u3002\u86cb\u767d\u8cea\u8840\u7ba1\u7dca\u5f35\u7d20II\uff08Ang II\uff09\u53ca\u5176\u53d7\u9ad4AT1\u548cAT2\u662f\u672c\u7cfb\u7d71\u7814\u7a76\u6700\u591a\u7684\u86cb\u767d\u8cea\u4e4b\u4e00\u3002AT2\u6572\u9664\u6c38\u751f\u5c0f\u9f20\u814e\u8fd1\u7aef\u5c0f\u7ba1\u7d30\u80de\u4fc2\u662f\u5f9e\u651c\u5e36\u733f\u7334\u75c5\u6bd2SV40\u5927T\u6297\u539f\u7684\u71b1\u4e0d\u7a69\u5b9a\u7a81\u8b8a\uff08tsA58\uff09\u7684\u5c0f\u9f20\u5206\u96e2\u7684\u689d\u4ef6\u6c38\u751f\u5c0f\u9f20\u814e\u8fd1\u7aef\u5c0f\u7ba1\u7d30\u80de\u3002 SV40\u5927T\u6297\u539f\u7684\u529f\u80fd\u8868\u9054\u662f\u901a\u904e\u5728\u5bb9\u8a31\u6eab\u5ea6\uff0833\u2103\uff09\u7684\u57f9\u990a\u57fa\u4e2d\u57f9\u990a\u542b\u6709IFN\u03b3\u7684\u57f9\u990a\u57fa\u4f86\u8a98\u5c0e\u7684\u3002\u5728\u4e0d\u5141\u8a31\u7684\u6eab\u5ea6\uff0837\u2103-39\u2103\uff09\u4e0b\uff0c\u7d30\u80de\u4e0d\u518d\u589e\u6b96\u3002\u7576\u8207\u91ce\u751f\u578b\uff08\u8ca8\u865fT0624\uff09\u548c\u5176\u5b83\u8840\u7ba1\u7dca\u5f35\u7d20\u53d7\u9ad4\uff08Ang II\uff09\u7f3a\u9677\u578b\u7d30\u80de\u7cfbAT1A – \/\uff08\u8ca8\u865fT0626\uff09\u914d\u5c0d\u6642\uff0c\u5c07AT1B – \/ – \uff08\u8ca8\u865fT0627\uff09\u548cAT1A – \/ – AT1B – \/ – \uff08\u8ca8\u865fT0628\uff09\uff0c\u9019\u4e9b\u7d30\u80de\u7cfb\u5728\u7814\u7a76\u8fd1\u7aef\u5c0f\u7ba1\u5340\u57df\u6d41\u9ad4\u548c\u96fb\u89e3\u8cea\u904b\u8f38\u7684\u6709\u50f9\u503c\u7684\u5de5\u5177\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u85e5\u7269\u6a19\u9776 | Drug Discovery-\u7d30\u80de\u5e73\u53f0\u7cfb\u5217\u5546\u54c1 Angiotensin Receptors Dr […]<\/p>\n","protected":false},"author":3,"featured_media":10272,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[457],"tags":[3699],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10270"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10270"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10270\/revisions"}],"predecessor-version":[{"id":10299,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10270\/revisions\/10299"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/10272"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10270"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}